Long-lasting clinical efficacy of allergen specific immunotherapy

Allergen-specific immunotherapy

Allergen-specific immunotherapy is a potentially disease-modifying therapy that is effective for the treatment of allergic rhinitis/conjunctivitis, allergic asthma and stinging insect hypersensitivity. However, despite its proven efficacy in these conditions, it is frequently underutilized in Canada. The decision to proceed with allergen-specific immunotherapy should be made on a case-by-case b...

Long-term efficacy of allergen specific immunotherapy in atopic dermatitis patients

Background Atopic dermatitis (AD) is an inflammatory, chronically relapsing, and highly pruritic skin disorder that considerably effects patients’ life. As the aeroallergens are relevant eliciting factors of not only respiratory allergy but also AD, allergen-specific immunotherapy (ASIT) seems to be a curative therapy option in treating AD. The efficacy of ASIT in AD patients has been poorly in...

Mechanisms of allergen-specific immunotherapy

Allergen-specific immunotherapy (SIT) is the only treatment, which leads to a life-long tolerance against allergens due to restoration of normal immunity. The induction of a tolerant state in peripheral T cells represents an essential step in allergen-SIT. Peripheral T-cell tolerance is characterized mainly by suppressed proliferative and cytokine responses against the major allergens and its T...

Long-term clinical and immunological effects of allergen immunotherapy.

PURPOSE OF REVIEW The present review updates current findings on long-term clinical and immunological outcomes after cessation of allergen immunotherapy for allergic respiratory disease. RECENT FINDINGS Recent studies have shown that allergen immunotherapy has sustained disease-modifying effects that persist for years after discontinuation. This is in contrast to the effects of antiallergic d...

Subcutaneous allergen specific immunotherapy – clinical efficacy assessment and side-effects and their prevention